Abstract
A latex-enhanced assay measuring free light chains (FLC) has recently become available and been reported to be sensitive and specific for detecting FLC diseases. Our aim was to compare this assay applied to 75 patients with FLC monoclonal gammopathies with the conventional techniques. In 100% of cases, quantification of FLC appeared to be informative. At the time of diagnosis, κ f/λ f ratio demonstrated in all cases the occurrence of a FLC disease. In 90% of cases where a Bence-Jones protein (BJP) was detected, the FLC ratio was abnormal. In 6 cases where the search for a BJP in urine was negative, the FLC ratio was abnormal. κ f–alpha-1-antitrypsin complexes and high molecular weight polymeric forms of BJP were shown to explain obvious overestimation of FLC quantitation. In conclusion, we suggest to combine with serum protein electrophoresis the measurement of FLC every time a FLC disease is suspected.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
