Apply research of 1H-MRS in brain injury of temporal lobe after radiotherapy

Abstract

Objective To study the diagnosis value of proton magnetic resonance spectroscopy (1H-MRS) on the temporal lobe brain tissue with radiation injuries of nasopharyngeal carcinoma (NPC), analyze the metabolites changes of temporal lobe brain tissue. Methods 1H-MRS examination was underwent on healthy group and temporal lobe brain injury after NPC radiotherapy group, analyze the ministry metabolites, such as N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) levels and the ratio each other. Healthy brain group include 10 persons, whose brain without any lesions. Temporal lobe injury after NPC radiotherapy group include 28 patients with temporal lobe brain lesions, the two groups were compared, using Philips Achieva superconducting magnetic resonance imaging device, select the point of spectroscopy (PRESS) acquisition sequence, acquire the brain magnetic resonance images in temporal lobe of healthy group, temporal lobe injury after radiotherapy group. Measure the values of NAA, Cr, Cho, NAA/Cr, Cho/Cr, NAA/Cho, and analyze them with statistics. Results The values of NAA, Cr, Cho, NAA/Cr, Cho/Cr, NAA/Cho in temporal lobe injury after radiotherapy group were 0.21±0.08, 0.27±0.23, 0.51±0.11,0.78±3.14,1.92±0.22 and 0.40±0.10, the values of NAA, NAA/Cr, NAA/Cho was lower than the normal healthy group, there were significant differences between the two groups(P<0.05).Compare with the normal healthy group, the value of Cho, Cho/Cr increased significantly(P<0.05). Conclusions 1H-MRS examination has a certain value to assessment the radiation brain injury after NPC radiotherapy. Key words: Magnetic resonance spectroscopy; Nasopharyngeal carcinoma; Brain injuries; Temporal lobe; Apply research