Applied value of lymph tracing material carbon nanoparticles in laparoscope midst-low position rectal cancer radical operation

Abstract

Objective To evaluate the value of lymph tracing material carbon nanoparticles (CNP)in laparoscopic radical operation for patients with mid-low rectal cancer.Methods Thirty patients with extraperitoneal rectal cancer were randomized into two groups:CNP group and control group.The former were injected with CNP through anus under the mucous membrane around lesion before the laparoscopic rectal cancer radical operation,and the latter underwent the laparoscopic rectal cancer radical operation according to the convention.The state of the lateral pelvic lymph tracing was observed.Operative time,the number of harvested lymph nodes,the number of metastatic lymph nodes and pathological stages between two groups were compared.Results 277 lymph nodes were harvested in the CNP group,while 218 lymph nodes in the control group.The mean of harvested lymph nodes in the CNP group was more than that in the control group(P ＜ 0.05).There was significant difference in the metastatic rate of lymph nodes(CNP group 60/277,21.66% vs control group 15/218,6.88%,P ＜ 0.05),and the pathological stages (P ＜ 0.05)between two groups.In 3 cases of the CNP group,the lateral lymph nodes were dyed black,and resected.One case was suspected of carcinoma and received the dissection of the lateral lymph nodes,and the pathological examination after operation confirmed the lymph nodes metastasis.Conclusion CNP may have potential value in the selective dissection of lateral lymph nodes in patients with midst-low rectal cancer,and also can increase the detection rate of metastastic lymph nedes,which can make the pathological statges after operation more accurate. Key words: Rectal carcinoma; Carbon nanoparticles; Laparoscope; Lymph node dissection