Abstract
Background Tissue Engineering is a multidimensional approach that aims to produce a structure similar to target tissue. Main targets in laryngeal tissue engineering (TE) are chronic vocal fold scars and vocal fold atrophy which occurs in elderly patients. The main obstacle for restoration is the highly complex architecture of the human vocal fold. Deterioration of its micro-architecture leads to altered vibration characteristics that have deleterious effects on voice quality, causing hoarseness (dysphonia). The aim of this study is to give an actual clinical and experimental overview of this field as well as to further elucidate promising new findings and trends.
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