Abstract
The rapid and accurate determination of bacterial spores in sterile environments (i.e., food preparation areas and hospitals) is of great importance in the minimization of bacteria-driven illnesses. Surface- Enhanced-Raman-Scattering (SERS) is potentially a very sensitive spectroscopic technique for the detection of biological threat agents. SERS can be made a more robust and attractive spectroscopic technique for biological threat agent sensing by developing high sensitivity, high reproducibility SERS-active substrates. The maturation of Si-based semiconductor fabrication techniques has facilitated the development and marketing of highly reproducible and sensitive SERS-active substrates. KlariteTM SERS-active substrates (Mesophotonics LTD) have been analyzed for utility in the potential identification of biological threat agents. Concurrently, we have investigated prototype SERS- active substrates under development by Nanospectra Biosciences, Inc. Substrate spatial reproducibility and substrate-to-substrate reproducibility will be discussed.© (2005) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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