Applications of single-cell multi-omics in cancer research

Abstract

Precision oncology, defined as molecular profiling of tumors to identify targetable alterations, is rapidly developing, and has entered the mainstream clinical practice. Genomic testing involves stakeholders workingnin a coordinated fashion to deliver high-quality tissue samples to laboratories, where appropriate next-generation sequencing (NGS) molecular analysis leads to actionable results. Clinicians should be familiar with the types of genomic variants reported by the laboratory and the technology used to determine the effects, including limitations of current testing methodologies and reports. Genomic results are best interpreted with multidisciplinary input to reduce uncertainty in clinical recommendations relating to a documented variant