Abstract
AbstractThis review summarizes the known commercial applications of rhodium-catalyzed olefin hydroformylation to fine chemical synthesis. Two manufacturing processes for Vitamin A utilize hydroformylation. Additional, recent examples of hydroformylation on multikilogram scale for synthesis of pharmaceutical building blocks have also been reported. Hydroformylation appears to be widely used in the fragrance industry, where aldehydes are ubiquitous. Numerous fragrance ingredients are commercially prepared by hydroformylation. There are no reports of agrochemical manufacturing processes which employ hydroformylation. In addition to commercial applications, examples of pharmaceutical, fragrance, and agrochemical products which have been prepared on small scale using hydroformylation are given. Hydroformylation appears to be well suited to fine chemical synthesis, and applications should increase as process chemists become more aware of its potential.KeywordsCarbonylationHydroformylationRhodiumSyngas
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