Applications of Next Generation CRISPR-derived Technologies.

Abstract

Human Gene TherapyVol. 31, No. 3-4 Calls for PapersFree AccessCall for Papers: Applications of Next Generation CRISPR-derived TechnologiesDue date for submissions: August 1, 2020Published Online:14 Feb 2020https://doi.org/10.1089/hum.2020.29106.cfp2AboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail CRISPR-based genome editing has revolutionized experimental biology and is being harnessed for human gene therapy. The fundamental capability of guiding a nucleotide-altering enzyme to a specific genomic or RNA sequence by means of a short RNA guide (sgRNA) allows for precise nucleic acid alterations to be made in human cells and a wide variety of different organisms. While initial applications of the CRISPR-Cas system were primarily based on the Cas9 endonuclease function, protein engineering has enabled a variety of other DNA- and RNA-altering functions to be guided by the Cas-sgRNA mechanism. Human Gene Therapy is now seeking original papers and review articles that describe the design, optimization, and application of these next-generation CRISPR approaches, including, but not limited to, the following technologies: Base editingEpigenome editingCRISPR-transactivationRNA editingPrime editingAnti-CRISPR proteinsNovel Cas-based fusion proteins that confer novel functions, sequence-targeted by Cas-sgRNADemonstrations of the utility of one or more of such technologies in animal models of specific human diseases, including monogenic disorders, is of particular interest.For questions regarding submissions or for technical assistance, contact HGT's Managing Editor: Mary Mazzanti at Mary.Mazzanti@umassmed.eduPlease visit our website for Instructions for Authors at www.liebertpub.com/HGT to assist with manuscript preparation.Submit all manuscripts for consideration via our peer review submission site: https://mc.manuscriptcentral.com/humFiguresReferencesRelatedDetails Volume 31Issue 3-4Feb 2020 InformationCopyright 2020, Mary Ann Liebert, Inc., publishersTo cite this article:Call for Papers: Applications of Next Generation CRISPR-derived Technologies.Human Gene Therapy.Feb 2020.132-132.http://doi.org/10.1089/hum.2020.29106.cfp2Published in Volume: 31 Issue 3-4: February 14, 2020PDF download