Abstract
Magnetic resonance spectroscopy (MRS) has clinically been most extensively used for assessing brain disorders, particularly tumors. With 1-H spectroscopy at intermediate echo times, resonances from choline, creatine, N-acetyl-aspartate (NAA), lactate, and free fatty acids can be resolved well enough to assist in diagnosis under routine conditions. Generally, an increased concentration of choline is found in all primary and secondary brain tumors, and the degree of increase correlates with the degree of anaplasia. Further indicators of anaplasia are the presence of lactate, indicating hypoxia, and of fatty acids, indicating necrosis. According to literature, the sensitivity of a combination of proton spectroscopy with contrast-enhanced dynamic susceptibility-weighted imaging for high-grade components in gliomas is better than conventional contrast-enhanced imaging alone. Today, proton spectroscopy is clearly indicated for differentiating radiation-induced damage from recurrences of irradiated brain tumors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
