Abstract
Bone tissue is a comprising of an organic and inorganic environment, in which the collagen element and the mineral part are structured into complex and spongy constructions. Hydroxyapatite (HAp) is the chief inorganic constituent of human bone. HAp is extensively utilized in bone tissue regeneration for its bioactivity and biocompatibility, and a rising number of investigators are discovering ways to recover the physical belongings and biological roles of HAp. However, this biomimetic material has poor mechanical properties, such as low tensile and compressive strength, which make it not suitable for bone tissue engineering (BTE). For this reason, HA is frequently utilized in a mixture with diverse polymers to increase their mechanical strengths and the general performance of the implantable biomaterials advanced for orthopedic usage. In this review, we attempt to contribute a brief and inclusive outline of HAp-based natural and synthetic polymer materials as reinforcing components and their applications in bone tissue engineering.
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