Applications of Chiral Cyclopentadienyl (Cpx) Metal Complexes in Asymmetric Catalysis

Abstract

Metal complexes containing cyclopentadienyl (Cp) ligands are versatile and robust catalysts widely applied in organic synthesis. During the last two decades chiral Cpx complexes have been applied in a variety of enantioselective transformations. Often associated with Group 9 metals (Co, Rh, Ir), chiral Cpx ligands have also been used in combination with early transition‐metals and rare‐earth elements. In this minireview asymmetric reactions that have been successfully steered with chiral Cpx ligand metal complexes are discussed according to the metal coordinated. Several ligand designs have successfully been used in a diverse array of reactions, in particular C–H functionalisation, with binaphthyl‐derived ligands leading this field. Challenges with these ligands derive from the need for their multi‐step synthesis, and recently new ligands were designed, which can be accessed in shorter sequences from readily available starting materials.