Abstract
Hypoxia and localized acidosis, increased interstitial pressure, perturbations in structure and function of the extracellular matrix, the production of growth factors and protein hydrolase, angiogenesis, and co-optation of the immune response are all microenvironment that promote tumor survival and metastasis. The application of animal models is critical to the understanding of the pathophysiology in these processes. This review will show the advances of animal models in the study of tumor microenvironment. Key words: Animal models; Tumor microenvironment; Pathophysiology
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