Abstract
Chitosan has unique physicochemical characteristics to make it safe and effective as a carrier of some drugs. However, some drawbacks restricted its applications in drug delivery systems. Chemical modifications occurred on the backbone of chitosan to overcome the disadvantages properties of chitosan. Chitosan derivatives were synthesized by inserting the hydrophobic moieties into the chitosan molecule. The resulting amphiphilic derivatives with low toxicity may form self-assembled nanoparticles that can deliver a drug to different body sites. The preparation and applications of the hydrophobic chitosan derivatives will be reviewed in this article.
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