Applications of 3D Printing Technology in Angiogenesis Model for Cancer Research

Abstract

3D printing is a technology that has gradually advanced with the development of technology and has been used in medicine and cancer treatment. 3D printing's ability to prototype quickly allows it to quickly convert fundamental cancer research findings into therapeutic applications, which could speed up or possibly completely transform the entire medication discovery and development process. Angiogenesis is an essential process in normal development and adult physiology but is disrupted in many diseases. The review summarizes the applications of 3D printing technology in angiogenesis models for cancer research. 3D printed PLA-bio-glass composite for bone tissue engineering can be used to study bone healing and regeneration. The in vitro microvascular model using 3D printing technology can be applied to explore the role of angiogenesis-related proteins. A 2D or 3D histological model is sufficient to track cancer cell dynamics. A combination of 3D bio-printed blood vessel models and spheroids can be a cost-effective and efficient method for drug testing to evaluate both tumor growth and angiogenesis. In future research, it can be expected to develop technologies to support 4D printing of personalized adjustable bionic periosteum with anisotropic microstructures to accelerate angiogenesis and bone healing.