Application values of S100-β protein, homocysteine and high-sensitivity C-reactive protein in diagnosis of ischemic stroke

Abstract

Objective To investigate the application values of S100-β protein, homocysteine (Hcy) and high-sensitive C-reactive protein (hs-CRP) in the diagnosis of acute ischemic stroke(AIS). Methods A total of 73 patients with AIS were enrolled in this study. The Non-stroke patients with similar symptoms were selected as control group (n=50). The relationship between levels of S100-β protein, Hcy and hs-CRP and infarct volume was evaluated. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic values of single and combined detection of these indicators in AIS. Results The levels of S100-β protein, Hcy and hs-CRP were higher in AIS patients than those in control group after adjusting the major vascular risk factors (P<0.05). There were significant differences in S100-β protein, Hcy and hs-CRP between different groups according to the infarct volume (P<0.05). S100-β protein, Hcy and hs-CRP positively were correlated with infarct volume (r=0.625, P=0.000; r=291, P=0.012; r=0.396, P=0.001 respectively). ROC curves showed that the diagnostic performances for AIS were as follows: S100-β protein (AUC=0.809, sensitivity: 65.8%, specificity: 82.0%), Hcy (AUC=0.775, sensitivity: 54.8%, specificity: 84.0%), hs-CRP (AUC=0.698, sensitivity: 58.9%, specificity: 78.0%) and Combined detection (AUC=0.878, the sensitivity: 68.5%, specificity: 94%). Conclusions S100-β protein, Hcy and hs-CRP protein can be used as biomarkers for AIS , which can help the diagnosis of AIS. S100-β protein can be used as a biomarker to evaluate the severity of AIS, Hcy and hs-CRP can also reflect the severity of AIS to some extent. Single detections of S100-β protein, Hcy and hs-CRP show limited value in the diagnosis of AIS. Combined detection gains a high specificity, but sensitivity is not very high. Key words: Stroke/ME; Acute disease; S100 proteins/ME; Homocysteine/ME; C-reactive protein/ME