Abstract
BackgroundThis study aims to investigate the application value of three-dimensional arterial spin labeling (3DASL) in investigating cerebral blood flow dynamics in full-term neonates.MethodsA total of 60 full-term neonates without known intracranial pathology were recruited for 3DASL examination. These neonates were divided into three groups: 1–3 day group, 4–7 day group, and 8–15 day group. On the cerebral blood flow (CBF) images, regions of interest (ROI) were selected from the frontal white matter, parietal white matter, basal ganglia, corona radiata, thalamus and brainstem, and the CBF values of each ROI were recorded. The CBF values of ROIs at bilaterally symmetric locations, the values of each ROI between males and females, and the values of each ROI among these three different age groups were compared.ResultsThe difference in CBF values of the frontal white matter, parietal white matter, basal ganglia, corona radiata and thalamus at the bilateral symmetric positions were not statistically significant. There was no statistical difference in the CBF values of each brain region between the male and female groups. The CBF values at the basal ganglia region, corona radiata and parietal white matter were higher in the 8–15 day group, when compared to the 1–3 day and 4–7 day groups (P < 0.05). The CBF value at the basal ganglia region was higher in the 4–7 day group, when compared to the 1–3 day group (P < 0.05). The CBF value at the frontal white matter was lower in the 4–7 day group, when compared to the 1–3 day and 8–15 day group (P < 0.05). The CBF value at the brainstem was higher in the 4–7 day group, when compared to the 1–3 day and 8–15 day groups (P < 0.05).ConclusionThe 3DASL can quantitatively measure CBF, and be used to evaluate cerebral hemodynamics in neonates. The basal ganglia region and corona radiata CBF increases with the increase in neonatal diurnal age.
Highlights
This study aims to investigate the application value of three-dimensional arterial spin labeling (3DASL) in investigating cerebral blood flow dynamics in full-term neonates
Three-dimensional arterial spin labeling (3DASL) has been widely used in central nervous system diseases, but studies on the value of 3DASL technology have mostly focused on adults, and few studies have been conducted on neonates [7, 8]
The cerebral blood flow (CBF) values of the basal ganglia region, corona radiata, hypothalamus and brainstem were slightly higher in females than in males, while the CBF values of the frontal and parietal white matter were slightly higher in males than in females
Summary
This study aims to investigate the application value of three-dimensional arterial spin labeling (3DASL) in investigating cerebral blood flow dynamics in full-term neonates. Arterial spin labeling (ASL) uses magnetically labeled arterial blood as an endogenous contrast agent, and uses water molecules as a free diffused internal tracer. It first induces reverse blood spin labels on the imaging plane. Wang et al BMC Pediatrics (2019) 19:495 the labeling of blood flow in brain tissues [5]. This technique has the following advantages: non-invasiveness, no need to inject the contrast agent, high safety, and its application to the neonatal brain perfusion imaging method [6]. Before the 3DASL sequence was used to analyze diseases, it was crucial to understand the hemodynamic performance of this sequence in normal human brains
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