Abstract

The pathogenesis of obstructive sleep apnea (OSA) includes anatomical and non-anatomical factors, and the arousal threshold (ArTH) is one of the important non-anatomical factors. At present, the main method is to assess the increased respiratory effort due to arousal to determine the arousal threshold, and invasive epiglottic or esophageal manometry is the gold standard, while the non-invasive continuous positive airway pressure (CPAP) method and polysomnography (PSG) ventilation signal conversion method are also widely used. Arousal threshold is expected to serve as an important evaluation index and potential target for drug therapy in OSA, which is of great importance for realization of precise treatment of OSA. This article focused on the method and clinical significance of OSA arousal threshold.

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