Abstract

As a new model organism, Zebrafish has been widely used in many aspects of life science research for its unique advantages in growth and development and the convenience of transgenic manipulation. Endemic disease is serious in China. Currently, on one hand, the pathogenesis of endemic fluorosis, endemic arsenism and iodine deficiency disorders is unclear, on the other hand, the cause of Keshan disease and Kashin-Beck disease is still unknown. This poses great difficulties in the prevention and control of endemic diseases. At present, there are some shortcomings and deficiencies in the animal models used to study the etiology and mechanism of endemic diseases. However, the advantages of Zebrafish as a new model organism just can make up for these deficiencies. Therefore, this paper reviews the application prospects of a new model organism, Zebrafish, in the field of endemic diseases. Key words: Zebrafish; Endemic fluorosis; Endemic arsenicosis; Iodine deficiency disorders

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