Abstract
Conventional orthopaedic and dental device materials are made of metallic materials such as stainless steel (SUS316L), titanium alloy (Ti-6Al-4V), and cobalt-chrome (Co-Cr). Those materials have the disadvantage of mechanical properties and anti-corrosion behavior. Bulk metallic glasses (BMGs), which are also called amorphous alloys, are metallic materials with metastable glassy states and have a higher strength, higher elasticity, higher failure resistance, and lower Young’s modulus compared with crystalline alloys. There are several types of BMGs. Among them, Zr-based BMGs and Ti-based BMGs have excellent mechanical properties. In addition, they have good corrosion resistance and are promising for orthopaedic and dental device materials. In this review article, in vitro and in vivo studies regarding Zr and Ti-based BMGs applications as biomaterials, especially in orthopaedic and dental device materials, are reviewed.
Highlights
Biomaterials are materials that are used for therapy and interact with biological systems
The results show that blood levels of Cu and Ni did not increase, and no findings of the biological effects were recognized including cell necrosis or dysplasia, infiltration of inflammatory cells, bone resorption, Metals
Formed bone is integrated between Strontium-substituted Bulk metallic glasses (BMGs) and the host bone. These findings indicated the good biocompatibility of Strontium-substituted BMGs and the possibility of application as artificial bone or a bioactive implant-like hydroxyapatite (HA) implant
Summary
Biomaterials are materials that are used for therapy and interact with biological systems. There are many device materials in which biomaterials are used, i.e., joint replacements, bone fixation devices, tooth fixation implants, blood vessel prostheses, and heart valves Those device materials need to be non-toxic, anti-corrosion, strong, and tough because they are continuously receiving a reaction from biological systems and bearing daily loadings. BMGs are prepared by extremely rapid cooling and solidification of melting liquid nucleation of crystals can be suppressed without a long-range atomic order The nucleation of and crystals atomic The structures, unique mechanical, physical,and chemical properties are can be suppressed without a long-range atomic order Due to their amorphous atomic structures, superior to conventional metallic alloys, i.e., crystalline alloys.
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