Abstract
The antihypertensive effect of sartans is a result of inhibition of the binding of angiotensin (AT) II to the AT1 receptor in vascular smooth muscle. The aim of current study is to apply the validated thin-layer chromatography (TLC)-densitometric method for simultaneous identification and determination of losartan potassium, telmisartan, and valsartan in tablets, by using the following chromatographic system:stationary phase:TLC plates with silica gel G60 F254, mobile phase: 7.5:1.5:5:5:0.01:0.03 = CHCl3-CH3OH-acetone-toluene-CH3COOH, ultraviolet detection at λ= 254 nm, and densitometer CAMAG. Accuracy is represented by the values of the degree of recovery R (%) and relative standard deviation (RSD). All data for R correspond to the relevant confidence interval $ - \bar X - t.S\bar X \div \bar X + t.S\bar X$: tablet Lorista® 99.43 ÷ 102.59, RSD = 1.15; tablet Losap®: 99.37 ÷ 101.87, RSD = 0.89; tablet Micardis®: 99.19 ÷ 99.97, RSD = 0.36; tablet Valtensin®: 98.74 ÷ 101.1, RSD = 0.85. Precision is estimate...
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