Application of unmodified boron-doped diamond electrode for determination of dopamine and paracetamol

Abstract

For the first time the application of unmodified boron doped diamond electrode for dopamine (DA) and paracetamol (PA) determination in biological samples and pharmaceutical preparations with the use of differential pulse voltammetry was demonstrated in the present work. The wide linear range of calibration graphs: from 1 × 10−7 to 2 × 10−4 mol L−1 for DA and PA, and very low detection limits were achieved, equaling 1.87 × 10−8 mol L−1 for DA and 1.35 × 10−8 mol L−1 for PA. The proposed sensor was successfully applied for determination of dopamine in urine samples, paracetamol in syrups for children, and for simultaneous determination of paracetamol and dopamine in blood and serum samples.