Application of ultrasound-guided fine-needle aspiration cytopathology combined with cell block immunohistochemistry in the diagnosis of lymph node lesions in elderly patients

Abstract

Objective To explore the clinical value of ultrasound-guided fine-needle aspiration(FNA) cytopathology combined with FNA cell block immunohistochemistry in diagnosing lymph node diseases for elderly patients. Methods A total of 55 elderly patients with lymph node lesions who were admitted to our hospital from January 2014 to February 2015 were treated by ultrasound-guided fine-needle aspiration. The obtained samples were sent for cytopathology, and FNA cell block was detected by immunohistochemistry. The diagnostic conclusions and the follow-up results were retrospectively analyzed and compared. Results The success rate of FNA cytology of this group was 96.4% (53/55). Among 53 patients, the results of cytological examination in 43 cases were consistent with the follow-up results. The coincidence rate of clinical diagnosis was 81.1% (43/53). The results of the cytology combined with cell block immunohistochemistry in 50 cases were consistent with the follow-up results. The coincidence rate of clinical diagnosis was 94.3% (50/53). The clinical diagnostic accordance rate of cytology combined with cell block immunohistochemistry was better than that of cytology alone (P<0.05). Conclusions Ultrasound-guided fine-needle aspiration cytopathology combined with FNA cell block immunohistochemistry in diagnosis of lymph node lesions is simple, practical, safe and reliable, which can significantly improve the diagnosis rate. It has a higher clinical application value and promotion prospects, especially for frail elderly patients. Key words: Ultrasonography; Lymph node; Immunohistochemistry