Application of tumor-associated antigen in immunodiagnosis of hepatocellular carcinoma

Abstract

Detection of antibodies to tumor associated antigen(TAA) in sera can be used for early diagnosis of cancer. For hepatocellular carcinoma, the sensivitity of any individual TAA rarely exceeds 20% ;with the successive addition of TAA to a final total of eight antigens(including c-myc, p53, cyclin B1, p62,Koc, IMPI, survivin, p16), antibody detection frequency is extremely increased and the sensivitity reaches 59. 9%. Thereby detection of autoantibodies in sera by using a mini-array of several TAAs as target antigens can be better used for early diagnosis of hepatocellular carcinoma, which provide a new approach not only to early immunodiagnosis of hepatocellular carcinoma but also to that of other cancers. Key words: Antigens,neoplasm ; Autoantibodies ; Immunologic tests ; Liver neoplasms ;