Abstract
Application of total error concept in the analytical method validation for the assay of essential amino acids by precolumn derivatization
Highlights
Amino acids are organic compounds consisting of nitrogen, carbon, hydrogen, and oxygen, together with the groups of variable side chains
A pre-Ultraperformance Liquid Chromatography (UPLC) column derivatization procedure was developed for the simultaneous quantification of essential amino acids (EAAs) in the solid oral dosage pharmaceutical formulation
This is an essential amino acid if phenylalanine is deficient in the diet
Summary
Amino acids are organic compounds consisting of nitrogen, carbon, hydrogen, and oxygen, together with the groups of variable side chains. Amino acids and proteins are the building blocks of life cycle. Essential amino acids (EAA) cannot be generated by the body; these shall be supplied through the diet (Essential Amino Acids, 2019). About 10 essential amino acids include histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, tyrosine, and valine which must be taken in the daily diet. Tyrosine is derived from phenylalanine by hydroxylation in the para position. Tyrosine is not included in the list of the EAA of the literature. This is an essential amino acid if phenylalanine is deficient in the diet
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