Abstract
Extracellular matrix (ECM) material with good biological activity is essential to simulate cell growth microenvironment, induce cell infiltration and angiogenesis, and promote the repair of large area acute skin wound. In this study, tilapia skin acellular dermal matrix (TADM) was prepared to simulate ECM microenvironment, which can promote substantial area acute wound healing in rats. The main component of TADM is type I collagen, which has good physical and chemical properties, biological activity and cell adhesion. TADM is a form of biomaterial with low immunogenicity, low risk of prion infection and lower economic cost than other related materials such as mammalian collagen biomaterials. Our results show that TADM can guide cell infiltration, angiogenesis, regulate the expression and secretion of inflammatory and skin repair correlated factors to promote tissue healing.
Highlights
Skin is the largest organ of the human body, and its structure is complex
A variety of studies have shown that collagen-rich fish skin materials have high biodegradability, so we judge that the obtained tilapia acellular dermal matrix (TADM) has a good application prospect in the field of acute wound repair and regenerative medicine
The results show that TADM and fetal bovine skin acellular dermal matrix (FBADM) have a large amount of tissue fluid infiltration on the third day, some inflammatory cells enter the scaffold along the larger pores, the structure of the scaffold is intact, and the fiber coating begins to form
Summary
Skin is the largest organ of the human body, and its structure is complex. As the first line of defense of human immunity, skin mainly acts as a barrier to the external environment (Morganti et al, 2019). 29 kinds of collagen have been found, among which type I collagen is widely found in skin, tendon, bone and other tissues (Alam and Jeffery, 2019; Lim et al, 2019). It can guide the directional growth of fibroblasts and other cells (Sapru et al, 2021). TADM Induce Skin Wound Repair and sea have been widely used, especially from land mammals such as humans, pigs and cattle. A variety of studies have shown that collagen-rich fish skin materials have high biodegradability, so we judge that the obtained TADM has a good application prospect in the field of acute wound repair and regenerative medicine. According to its characteristics, acute skin wound repair experiments were carried out in SD rats to verify the biological properties of TADM
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
