Abstract
Abstract The shrinking-core model has been applied to the frontal analysis (unsteady-state fixed-bed breakthrough for step input) of protein ion-exchange systems. The model is specific to processes that involve removal of the counter ion from slution by strong association with fixed ions. The system equations have been solved numerically for the breakthrough of bovine serum albumin (BSA) on Sephadex A50. Protein liquid and particle diffusivities have been estimated from experimental data reported in the literature. The breakthrough curve predictions give a good approximation to the experimental observations. Comparison is also made using a two-resistance model which gives excellent agreement with the experimental observations. However, this model requires that an effective particle diffusivity be determined by a separate batch kinetic experiment. Since the shrinking-core model requires no such separate parameter determination it is considered better as a predictive model for protein adsorption for the system studied.
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