Application of the novel organic network material for the detection of fluoroquinolone antibiotics in milk

Abstract

<p indent=0mm>The residues of fluoroquinolone antibiotics in milk increase the risk of dietary exposure. The development of detection technology is an important guarantee of food safety. In this work, 1,3,5-triacetylbenzene and 2,4,6-triiodophenol were selected as monomers to synthesize new organic network materials based on Sonogashira coupling reaction under moderate condition of <sc>30 °C.</sc> Morphology, structure and hydrophobicity of the prepared material were characterized. Due to the π-π, hydrogen bonding and hydrophobic interaction, fluoroquinolone antibiotics in milk can be absorbed efficiently on the material. As an adsorbent of solid phase extraction (SPE), the pipette-tip SPE conditions were optimized combined with high performance liquid chromatography coupled with fluorescence detector, and the novel method for the detection of fluoroquinolone antibiotics in milk was established. The linear range was <sc>0.4–100 μg/kg,</sc> and <italic>R</italic>²<x content-type=symbol>³</x>0.9992 showed the good linear relationship. The detection limit was <sc>0.15–1.2 μg/kg.</sc> The recoveries and relative standard deviations were 89.6%–103.5% and 1.3%–5.9%, respectively. It was suitable for the determination of fluoroquinolone antibiotics in milk samples.