Abstract
The weight of evidence points to weak genotoxic activity of methyleugenol, the putative genotoxic carcinogen being 1′-sulphate ester metabolite. Dose response modelling of the data for methyleugenol gave a BMDL10 for male rat liver adenoma or carcinoma (combined) of 7.9 mg/kg-bw/d following adjustment to daily average doses. The MoEs ranged from 100 to 800 depending on the assumptions used in the exposure estimation.
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