Abstract
BackgroundHealth technology assessment (HTA) is currently one of the major challenges in assessing medical innovations and healthcare systems. In Europe, the European Network for Health Technology Assessment (EUnetHTA) has been aspiring to develop and implement standards for international sharing of HTA results and studies. Slovakia and many other EU countries do not have an established HTA system yet. This paper is focused on an exact description of the EUnetHTA Core Model individual domains applied to the process of selecting patients in the terminal stage of prostate cancer for Radium-223 treatment under particular conditions of the Institute of Nuclear and Molecular Medicine (INMM) in Košice, Slovakia.ResultsWe produced the first pilot HTA report using the HTA Core Model in Slovakia. The main objective was to collect all relevant information on the particular technology, and provide its summary to the interested stakeholders on one spot. Rather than applying detailed individual items, i.e. assessment elements and assessment element cards, we concentrated on the content of individual domains and tried to fill them with the best country, facility and intervention related data. The dataset consisted of 52 patients that finished the treatment in the period 2015–2017. The patients were carefully selected according to the Radium-223 producer’s criteria. Only 33 patients received the full therapy consisting of six applications; their average survival was 10.5 months from the application of the last dose.ConclusionsBased on the results of our analyzes, we recommended several changes to the INMM processes and patient follow-up checks during the treatment process in order to make the therapy more effective. The greatest benefit is expected after the implementation of a 68Ge/68Ga generator in 2018, as the selection of patients suitable for the Radium-223 treatment will improve. We showed that the HTA Core Model can be implemented in Slovakia, even under conditions of no formal HTA support or institutionalization.
Highlights
Health technology assessment (HTA) is currently one of the major challenges in assessing medical innovations and healthcare systems
The EUnetHTA HTA Core Model is a methodological framework developed by the EUnetHTA European network to standardize HTA reports within the European Union (EU) in order the HTA studies could be conducted in a structured, uniform format [18, 29]
Rather than applying detailed individual items and assessment element cards, we concentrated on the content of individual domains and tried to fill them with the best country, facility and intervention related data
Summary
In the context of improving the efficiency of provided health care services, health systems of advanced countries constantly apply new scientific, research and professional information from many disciplines. Health technology assessment (HTA) is currently one of the major challenges in assessing medical innovations and healthcare systems It is a rapidly evolving multidisciplinary applied-science discipline that evaluates and assesses health technologies and interventions in the context of clinical, ethical, economic, social, legislative, organizational and other parameters, the domains of the rating [5, 13]. It informs decision makers about the benefits, risks and costs of new technologies. HTA must always be based on findings and outputs of research and application of scientific methods
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