Abstract

Relevance. Inflammation of the mammary gland — mastitis — in cows is widespread. Of particular danger is subclinical mastitis, which proceeds latently, without visible clinical signs. During one, two or more lactations, subclinical mastitis leads the affected quarter to agalactia and atrophy. Animals that had subclinical mastitis lose milk productivity by an average of 10–15%; along with a decrease in milk secretion in animals with subclinical mastitis, its qualitative characteristics also change. Materials and methods. The work was carried out in the livestock economy of Dagestan Republic on black-and-white Holsteinized cows aged from three to six years, suffering from subclinical mastitis, in the amount of 42 heads, divided into two groups (experiment and control). The cows of the experimental group ( n = 25) were injected intracisternally with Enroflon ® gel in dose of 7.5 ml (syringe-dispenser) twice a day for 3–4 days. Control animal ( n = 17) were injected into the affected quarter of the udder with Mastisan A in dose of 10 ml once a day until recovery. The diagnosis of the disease was established in accordance with the “Manual on the diagnosis, therapy and prevention of mastitis in cows” (M., 2000). Blood and udder secretions were taken from 5 cows of each group before the administration of the drugs and on the 5th day after the end of treatment for laboratory research. The suprauterine lymph nodes were examined by palpation. Research results. As a result of production tests, Enroflon ® gel showed a high therapeutic efficiency (96,0%), hematological and biochemical parameters of blood and physicochemical — of milk recovered completely on the fifth day after treatment.

Highlights

  • The cows of the experimental group (n = 25) were injected intracisternally with Enroflon® gel in dose of 7.5 ml twice a day for 3–4 days

  • The diagnosis of the disease was established in accordance with the “Manual on the diagnosis, therapy and prevention of mastitis in cows” (M., 2000)

  • Blood and udder secretions were taken from 5 cows of each group before the administration of the drugs and on the 5th day after the end of treatment for laboratory research

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Summary

VETERINARY PHARMACOLOGY

Применение препарата Энрофлон® гель для лечения коров, больных субклиническим маститом. Две и более лактации, субклинический мастит приводит пораженную четверть к агалактии и атрофии. Животным опытной группы (n = 25) вводили интрацистернально препарат Энрофлон® гель в дозе 7,5 мл (шприц-дозатор) два раза в сутки в течение 3–4 дней. Коровам контрольной группы (n = 17) вводили в пораженную четверть вымени препарат Мастисан А в дозе 10 мл один раз в сутки до выздоровления. От 5 коров каждой группы до введения препаратов и на 5-й день по окончании лечения отобрали пробы крови и секрета вымени для лабораторного исследования. В результате производственных испытаний препарат Энрофлон® гель показал высокую терапевтическую эффективность (96,0%), гематологические и биохимические показатели крови и физико-химические — молока восстановились полностью на пятый день после лечения.

Materials and methods
ВЕТЕРИНАРНАЯ ФАРМАКОЛОГИЯ
Повторное лечения голов
Мастисан А
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