Abstract
目的 研究胸水和血清细胞角蛋白片段19(CK-19)等指标在非小细胞性肺癌(NSCLC)实验室诊断中的应用价值.方法采用ELISA法检测45例NSCLC、50例良性肺疾病患者血清和胸水中CK-19水平,30例健康体检者血清CK-19水平,同步测定了乳酸脱氢酶(LDH)、腺苷脱氨酶(ADA)、C反应蛋白(CRP)、癌胚抗原(CEA)、免疫球蛋白E(IgE)水平,进行显著性检验及相关性分析.结果 NSCLC组血清和胸水中CK-19、CEA和LDH水平均明显高于良性肺疾病组(p<0.05),而血清ADA水平均低于良性肺疾病组和健康对照组(p<0.05).良性肺疾病组血清和胸水CRP水平明显高于NSCLC组(p<0.05).胸水中CK-19水平与血清CK-19水平高度相关(NSCLC组r=0.868;良性肺疾病组r=0.5462).胸水和血清CK-19对肺癌的诊断敏感性、特异性和准确性分别为93.3%和71.1%、91.7%和87.5%、92%和81.6%.结论胸水和血清CK-19检测对NSCLC的诊断是一个较好的指标,联合检测相关指标有助于临床诊断。
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