Application of the combinatorial approaches of medicinal and aromatic plants with nanotechnology and its impacts on healthcare.

Abstract

Medicinal and aromatic plants are natural raw materials. Since ancient times these herbal materials are being commonly used as herbal drugs, food products, and cosmetics. The phytomolecules isolated from the medicinal and aromatic plants (MAPs) are in high demand specifically in drug industries. However, these phytomolecules have certain limitations of low absorption, high toxicity, and other side effects, bioavailability and efficacy. These limitations may be overcome by using nanotechnological tools. The plant extract or essential oil of MAPs are also useful in the synthesis of nanoparticles. In future this combinatorial application of MAPs and nanotechnology would be advantageous in thehealthcare area. Literature search was performed using databases like Pubmed, Scopus and Google Scholar with the keywords "nanoparticles," "phytomolecules," "medicinal and aromatic plants" and "green synthesis of nanoparticles" in the text. Phytomolecules of medicinal and aromatic plants like curcumin, camptothecin, thymol, and eugenol have certain limitations of bioavailability, efficacy, and solubility. It limits its biological activity and therefore application in the biomedical area. The increment in the biological activity and sustained delivery was observed after the encapsulation of these potent phytomolecules encapsulated in the nanocarriers. Besides,MAPs and/or their molecules/oils mediate the synthesis of metal nanocarriers with less toxicity. This review highlights the impact of the combination of the MAPs with the nanotechnology along with the challenges. It would be an effective technique for the efficient delivery of different phytomolecules and also in the synthesis of novel nano-materials, which escalates the opportunity of exploration of potential molecules of MAPs. Graphical abstract Graphical representation of the combinatorial approach of MAPs and nanotechnology.