Abstract
Tissue engineering using whole, intact cell sheets has shown promise in many cell-based therapies. Avoiding the use of enzymes, expended cells can be harvested together with endogenous extracellular matrix, cell-matrix contacts and cell-cell contacts. Currently, the cell sheet engineering has already been applied in various diseases, including the cornea, esophagus, heart, periodontal ligament, and cartilage. However, several challenges stand in the way of the vascularization of the big mass constructs, the industrialization of cell sheet products and the widespread acceptance of regenerative medicine based on cell sheet engineering. In this review, we introduce recent progress in the engineering of cell sheets and propose the directions of cell sheet technology in foundation and clinical studies. Key words: Cell sheet; Tissue engineering
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