Application of synthetic and semisynthetic polymers (Kollidon K30 and hydroxypropylmethylcellulose) as carriers of ketoprofen in solid oral prolonged-release dosage forms

Abstract

One of the most important challenges of the modern technology of solid oral dosage forms is to increase the effectiveness of the drug, reduce side effects and improve the comfort of use. One way to obtain such effects are prolonged release dosage forms. The aim of the study was to investigate the suitability of polymers (synthetic - Kollidon K30 and semisynthetic - hydroxypropyl methylcellulose), and calcium hydrogen phosphate dihydrate - as an inorganic insoluble filler - in the construction of the matrices of the solid oral dosage forms containing non-steroidal anti-inflammatory drugs (NSAIDs). We used ketoprofen as a model active ingredient. Ketoprofenum, hydroxypropylmethylcellulose, calcium hydrogen phosphate, kollidon K30, magnesium stearate. Incorporation. Studies of the tablet mass. Direct tabletting. Studies of the pharmacopoeial parameters and pharmaceutical availability. Measurements of the viscosity of 1% solution of HPMC and Kollidon K30. Approximation of the results. We obtained three versions (formulations) of the matrices. The results of the granulometric research on tablet formulations were consistent with the standards. The results of morphological studies and pharmacopoeial tablets were consistent with the standards. The best results were obtained for the release formulations containing HPMC and calcium hydrogenphoshate. Kollidon K30 accelerated the release of ketoprofen from tablets of formulation I. The model system of preformulation studies showed the usefulness of HPMC and Kollidon K30 in the technology of hydrophilic matrices with ketoprofen.