Abstract
The coupling of high-performance liquid chromatography (HPLC) and atmospheric pressure ionisation mass spectrometry (API-MS) seems to be the method of choice if good separation and selective detection of semi-volatile, thermolabile, and polar substances is required. Libraries of mass spectra will make the identification of unknown substances in complex environmental samples easier and more user-friendly. Unfortunately, existing GC–MS libraries are not applicable to HPLC–API-MS analysis. Thus, new and extensive mass spectral libraries were constructed. Several investigations of chromatographic (composition and salt concentration of the eluent) as well as mass spectrometric (orifice voltage) parameters and a few applications of real environmental samples are used to discuss the possibilities and limits of these libraries.
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