Abstract
Simple and rapid quantitative procedure based on gas chromatography mass spectrometry in combination with static headspace was developed for the identification of paracetamol and its impurities in commercially available analgesic tablets. The proposed procedure provides relevant analytical results and an uncomplicated sample procedure. Samples were separated on HP5-ms capillary column using helium (1.5 ml min-1) as carrier gas. The qualitative identification of analysed compounds was carried out on a triple quadrupole mass spectrometer in scan mode equipped with electron impact ionisation (EI) and recognised by NIST Library (NIST Library match > 90%). The elaborated procedure is suitable for the identification of paracetamol, its impurities (N-phenylacetamide. N-(2-hydroxyphenyl)acetamide) and volatile organic compounds.
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