Application of serum nucleobindin-2 in the diagnosis of nasopharyngeal carcinoma

Abstract

Objective To investigate the expression level of nucleobindin-2 (NUCB2/Nesfatin-1) in nasopharyngeal carcinoma (NPC) patients, other patients with head and neck cancer, rhinitis patients, and healthy subjects in the serum, and evaluate the clinical application value of NUCB2/Nesfatin-1 combined with three items of Epstein-Barr (EB) virus (EA-IgA; VCA-IgA; Rta-IgG) in NPC diagnosis. Methods From Xiangya Hospital of Central South University during January 2017 to June 2017, nasopharyngeal carcinoma patients, other patients with head and neck cancer, rhinitis patients, and healthy subjects samples were 140 cases, respectively. The corresponding kits were used to detect nesfatin-1, EA-IgA, VCA-IgA, and Rta-IgG. Results The serum level of nesfatin-1 in NPC patients was the highest, and the difference was statistically significant compared to other groups. The serum levels of EA-IgA, VCA-IgA, and Rta-IgG were the highest in NPC patients, and were significantly different from those in other groups. Nesfatin-1 was significantly correlated with VCA-IgA and Rta-IgG. There was no significant correlation between nesfatin-1, EA-IgA and NPC staging; Multiple linear regression analysis was used to analyze the influencing factors of nesfatin-1, and the regression equation was Y=208.029+ 17.96X1+ 146.702X2+ 398.879X3 (X1: age; X2: VCA-IgA; X3: Rta-IgG; R2=0.236). Receiver operating characteristic (ROC) curve analysis showed that nesfatin-1 combined with VCA-IgA and Rta-IgG had the best efficiency in the diagnosis of NPC. In single index evaluation, nesfatin-1 has the lowest specificity, but the highest sensitivity. Conclusions The sensitivity of nesfatin-1 for NPC diagnosis is polar altitude, it can make up for the deficiency of EA-IgA, VCA-IgA, and Rta-IgG in diagnosing NPC. The combination of VCA-IgA and Rta-IgG can greatly improve the ability of diagnosing NPC. Key words: Nuclear proteins/DU; Nasopharyngeal neoplasms/DI