Abstract
Abstract Coumarins (2H-1-benzopyran-2-coumarin derivatives) are derivatives of cinnamic acid naturally occurring in many plants, fungi, and fruits. They are used as ingredients in cosmetics to enhance the aroma and other biological effects. In this work, cosmetic samples (deodorants) were treated by solid phase extraction prior to high performance liquid chromatography determination of coumarins. Traditional sorbent (C18) and selective polymer-based sorbents (laboratory prepared and commercial) were used for solid phase extraction. Recovery values were above 85 % (RSDs below 6 %) except for esculin, where the recovery was lower. Core-shell column of C18 type and gradient of mobile phase methanol—1 % acetic acid were used for high performance liquid chromatography analysis of extracts. Limits of quantitation were 0.5 µg mL−1 for coumarin (ultraviolet detection) and below 12 ng mL−1 for esculin, umbelliferonene, scoparone, 4-methylumbelliferone, herniarin (fluorescence detection). In the tested samples, no coumarins were detected.
Highlights
Coumarins (Fig. 1) are substances naturally occurring in plants, and other natural sources
Selection of solid phase extraction (SPE) sorbent Commercial SPE sorbents, C18 Hydra, molecularly imprinted polymers (MIP)-phenolics and laboratory prepared MIP-coumarins were tested for coumarins extraction from deodorant samples
Extraction efficiencies of SPE sorbents were evaluated for standard solution of coumarin at the concentration level of 2.0 μg mL–1 and esculin, um belliferone, scoparone, 4-methylumbelliferone, herniarin at the concentration level of 20 ng mL–1
Summary
Coumarins (Fig. 1) are substances naturally occurring in plants (e.g. tonka bean, yellow sweet clover, lavender), and other natural sources. They exhibit several biological effects with a wide range of applications, e.g. UV protection, antibacterial, nematocidal, phytotoxic, antifungal activity, etc. Coumarins improve the aroma of the products, but from a technological point of view they serve mainly as a modifier and fixator of the final fragrant composition. A quantitative human health risk assessment integrating both cancer and non-cancer effects confirmed the safety of coumarin exposure from natural dietary sources as well as from its use as perfume in personal care products (Felter et al, 2006)
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