Abstract
BackgroundPresent work describes a fast, simple, and sensitive procedure for the simultaneous determination of cetirizine in the presence of quinolones using diclofenac sodium as an internal standard. The present work was designed to analyze these compounds in pharmaceutical and clinical labs being economical for use.ResultsThe mobile phase consisted of the simple composition of methanol, acetonitrile, and water in a ratio of 50:20:30 with a pH adjusted to 3.1 at a flow rate of 1 mL min−1. The UV detection was performed at 225 nm. The linearity was assessed over the range of 2.5–50 μg mL−1 for all drugs. The parameters such as accuracy, precision, linearity (>0.999), and sensitivity were satisfactory.ConclusionThe method was equally applicable for formulation and human serum with recovery values between 95 and 105%. The results of the method were validated statistically according to ICH guidelines.
Highlights
Present work describes a fast, simple, and sensitive procedure for the simultaneous determination of cetirizine in the presence of quinolones using diclofenac sodium as an internal standard
Cetirizine (Fig. 1), an H1-receptor antagonist, is coadministered with quinolones in several cases; drug-induced urticaria has been reported with a wide range of drugs and vaccines
It has been reported that most patients with multiple drug allergy syndrome and more than one-third of subjects with a history of hypersensitivity to a single antibacterial drug were characterized by circulating histamine-releasing factors
Summary
Present work describes a fast, simple, and sensitive procedure for the simultaneous determination of cetirizine in the presence of quinolones using diclofenac sodium as an internal standard. It has been reported that most patients with multiple drug allergy syndrome and more than one-third of subjects with a history of hypersensitivity to a single antibacterial drug were characterized by circulating histamine-releasing factors, the administration of several drugs (six H1receptor blockers, seven beta-adrenergic antagonists, four analgesics, ten diuretics, and five quinolones) which modulate the function of P-glycoprotein to patients may adversely affect the natural process of this efflux pump. It may cause drug-drug interactions induced side effects [6]. It became apparent to develop a method wherein simultaneous quantification of cetirizine in the presence of quinolones could be accomplished
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