Abstract
In XANTUS study the safety and efficacy of factor Xa inhibitor rivaroxaban were evaluated in routine clinical practice in patients with non-valvular atrial fibrillation. In consecutive patients who started treatment with rivaroxaban, all adverse events were recorded every 3 months for 1 year. Conclusions of major bleeding, symptomatic thromboembolic complications (stroke, systemic embolism, transient ischemic attack, and myocardial infarction) and death from all causes were centrally adjudicated. In total 6784 patients were treated with rivaroxaban at 311 centers in Europe, Israel, and Canada, on average, 329 days. The mean CHADS2 and CHA2DS2-VASc scores were 2.0 and 3.4, respectively. Treatmentemergent major bleeding occurred in 128 patients (2.1 events per 100 patient-years), 118 (1.9 events per 100 patient-years) died, and 43 (0.7 events per 100 patient-years) suffered a stroke. XANTUS is the first international, prospective, observational study to describe the use of rivaroxaban in a broad non-valvular atrial fibrillation patient population. Rates of stroke and major bleeding were low in patients receiving rivaroxaban in routine clinical practice.
Highlights
В исследовании XANTUS оценены безопасность и эффективность ингибитора фактора Xa ривароксабана в обычной клинической практике у пациентов с неклапанной фибрилляцией предсердий
Sedina ul. 4, Krasnodar, 350063 Russia In XANTUS study the safety and efficacy of factor Xa inhibitor rivaroxaban were evaluated in routine clinical practice in patients with non-valvular atrial fibrillation
In total 6784 patients were treated with rivaroxaban at 311 centers in Europe, Israel, and Canada, on average, 329 days
Summary
ПРИМЕНЕНИЕ РИВАРОКСАБАНА В РЕАЛЬНОЙ КЛИНИЧЕСКОЙ ПРАКТИКЕ: РЕЗУЛЬТАТЫ ПРОСПЕКТИВНОГО НАБЛЮДАТЕЛЬНОГО ИССЛЕДОВАНИЯ XANTUS У БОЛЬНЫХ С ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ. В исследовании XANTUS оценены безопасность и эффективность ингибитора фактора Xa ривароксабана в обычной клинической практике у пациентов с неклапанной фибрилляцией предсердий. XANTUS – первое международное проспективное обсервационное исследование, описавшее применение ривароксабана в широкой популяции пациентов с неклапанной фибрилляцией предсердий. In XANTUS study the safety and efficacy of factor Xa inhibitor rivaroxaban were evaluated in routine clinical practice in patients with non-valvular atrial fibrillation. XANTUS - является первым международным проспективным неинтервенционным исследованием, в котором оценивали влияние ривароксабана на частоту массивных кровотечений и тромбоэмболических осложнений у больных с ФП в рутинной клинической практике. The use of rivaroxaban in clinical practice Применение ривароксабана в реальной клинической практике множественной сопутствующей патологией, высоким риском как тромбоэмболических, так и геморрагических осложнений. Недавно в European Heart Journal представлены результаты исследования XANTUS [9]
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