Abstract
The development of cancer treatment methods is constantly changing. For common cancers, our treatment methods are still based on conventional treatment methods, such as chemotherapy, radiotherapy, and targeted drug therapy. Nevertheless, the emergence of tumor resistance has a negative impact on treatment. Regulated cell death is a gene-regulated mode of programmed cell death. After receiving specific signal transduction, cells change their physical and chemical properties and the extracellular microenvironment, resulting in structural destruction and decomposition. As research accumulates, we now know that by precisely inducing specific cell death patterns, we can treat cancer with less collateral damage than other treatments. Many newly discovered types of RCD are thought to be useful for cancer treatment. However, some experimental results suggest that some RCDs are not sensitive to cancer cell death, and some may even promote cancer progression. This review summarizes the discovered types of RCDs, reviews their clinical efficacy in cancer treatment, explores their anticancer mechanisms, and discusses the feasibility of some newly discovered RCDs for cancer treatment in combination with the immune and tumor microenvironment.
Highlights
With the increase in the incidence of various types of cancer such as breast, kidney, and lung cancers, cancer therapy has always been the focus of clinical development [1]
Necroptosis is a caspase-independent form of regulated cell death (RCD) that is driven by the activation of receptor-interacting protein kinases (RIPs) and mixed lineage kinase domain-like (MLKL) [43–45]
The application of RCD in cancer is mainly to promote the process of death, there is still a part of RCD that promotes the effect of cancer; we cannot induce cell death for cancer treatment
Summary
With the increase in the incidence of various types of cancer such as breast, kidney, and lung cancers, cancer therapy has always been the focus of clinical development [1]. Many researchers have realized that promoting the death of cancer cells is a feasible way to treat cancer [3]. It has been proven to be feasible for guiding the new direction of cancer treatment [8]. Because of their different molecular mechanisms, different types of RCDs can often be used as therapeutic alternatives to each other [9]. Many studies have shown that lipid metabolism is closely associated with some RCDs, such as apoptosis and ferroptosis [14–16]. Targeting lipid metabolism to induce cancer cell death in cancers that are sensitive to lipid metabolism can be an adequate therapeutic approach. This review discusses the possibility of application of various RCDs including lipid metabolism and cellular immunity in cancer treatment
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