Abstract
Gastric cancer ranks as the fifth most common malignant tumor worldwide and is the third most common cause of cancer-related death. For advanced gastric cancer (AGC), neoadjuvant chemotherapy (NAC) can reduce its stage, increase the rate of radical resection, improve response to treatment, reduce the risk of local recurrence and improve survival rate. Regional arterial infusion chemotherapy (RAIC) is a form of NAC that involves directly injecting chemotherapeutic drugs into the tumor site through the tumor-feeding artery. RAIC increases the local drug concentration around the tumor, thereby improving the therapeutic responses and reducing the adverse effects of the drugs. In recent years, RAIC has attracted increasing attention. This article summarizes the basic principles, procedure, chemotherapy regimens, adverse drug reactions and complications, clinical applications and response evaluation of RAIC in the treatment of AGC.
Highlights
Gastric cancer ranks as the fifth most common malignant tumor worldwide and is the third most common cause of cancer-related death [1]
Regional arterial infusion chemotherapy (RAIC) is a method of injecting chemotherapeutic drugs directly into the tumor tissue through a tumor-feeding artery to increase the concentration of the chemotherapy drug at the tumor lesion
A postoperative survey demonstrated that the 5-year survival rate of GC patients in the RAIC group was significantly increased compared with the untreated group
Summary
Gastric cancer ranks as the fifth most common malignant tumor worldwide and is the third most common cause of cancer-related death [1]. Surgical resection is still considered the only cure for gastric cancer. The symptoms of gastric cancer are not obvious. Most gastric cancers are diagnosed in the late-stage, when surgical treatments are not available options. Neoadjuvant chemotherapy (NAC) improves the rate of radical resection and long-term survival. Regional arterial infusion chemotherapy (RAIC) is a method of injecting chemotherapeutic drugs directly into the tumor tissue through a tumor-feeding artery to increase the concentration of the chemotherapy drug at the tumor lesion. RAIC improves the curative effect and reduces the adverse effects of chemotherapy drugs. RAIC has attracted increasing attention [3]-[9]. This article summarizes the basic principles, procedure, chemotherapy regimens, adverse drug reactions and complications, clinical applications and response evaluation of RAIC in the treatment of AGC
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