Abstract
Maintenance of dental health has attracted attention of researchers at present. Various materials have been constructed and applied for curing different dental diseases, although limitation of biocompatibility and safety is still a big challenge. To overcome these limitations, nanomaterials with unique properties are incorporated into various dental treatment materials used in dental applications, including endodontic treatment, periodontal treatment, implant treatment, oral surgery, and restorative treatment, etc. Especially, reactive oxygen species-based nanomaterials equipped with nanoscale properties and reactive oxygen activities can be used as sterilization agents in dentistry, along with being used as good fillers in the dental field. This review concludes the common reactive oxygen species (ROS) nanomaterials and reviews the utilization of ROS in dentistry, highlighting the potential application and safety in clinical treatment. The future prospect will also be proposed to conduct the clinic dental cure.
Highlights
Dental diseases like dental caries and periodontal diseases are the widespread issues at present caused by bacteria
Bacteria are adhered to the tooth surface leading to destruction of tooth structure presented by means of the aggregation of the microorganism known as oral biofilm, dental plaque [1,2]
Tooth demineralization is always followed by the loss of calcium and phosphate from enamel and dentin, while the calcium and phosphate lost by enamel will be deposited again into the tooth during remineralization process [4]
Summary
Dental diseases like dental caries and periodontal diseases are the widespread issues at present caused by bacteria. Tooth demineralization is always followed by the loss of calcium and phosphate from enamel and dentin, while the calcium and phosphate lost by enamel will be deposited again into the tooth during remineralization process [4]. If this accumulation and/or mineral dissolution process is not stopped, serious oral disease will be caused [5]. At low or moderate concentration, ROS have positive effects such as tissue repair, cell differentiation, angiogenesis, and vascular endothelial growth factor (VEGF) induced cell migration, while at a high concentration, uncontrolled cell activity may cause cell death and disease, carcinogenesis, mitochondrial dysfunction. ROS are generated as a cellular response, but are products of normal metabolism in cells [18]
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