Application of radial endobronchial ultrasound with distance transbronchial biopsy in diagnosis of peripheral pulmonary lesions

Abstract

Objective To evaluate efficacy, safety and influencing factors of radial endobronchial ultrasound with distance transbronchial biopsy (REBUS-D-TBB) in the diagnosis of peripheral pulmonary lesions (PPLs). Methods Clinical data of 65 patients with PPLs who underwent REBUS-D-TBB in the First Affiliated Hospital of China Medical University from April 20, 2017 to April 28, 2018 were retrospectively analysed to evaluate its diagnostic yield, safety and influencing factors. Results The overall diagnostic yield was 58.5%(38/65) in REBUS-D-TBB for PPLs, and the diagnostic yield was 71.1%(32/45) for malignant tumors and was 33.3%(6/18) for benign diseases.Lesion size (diameter >20 mm), probe position (within the lesions) and the number of biopsies (>5) influenced the diagnostic yield, distribution of lesions in the lobe showed no significant effect on diagnostic yield.Moderate bleeding (about 50 ml) was observed in two patients after biopsy, and bleeding stopped after hemocoagulase was sprayed locally, the remaining patients showed only a small amount of bleeding after biopsy which stopped spontaneously. Conclusions REBUS-D-TBB is both effective and safe in the diagnosis of PPLs, chosing suitable patients can improve the diagnostic yield. Key words: Endobronchial ultrasound; Transbronchial biopsy; Peripheral pulmonary lesions; Diagnosis