Abstract
Objectives: The main purpose of this work is to design a simple, sensitive, accurate and precise potentiometric membrane ion selective electrodes for selective determination of loperamide hydrochloride in bulk powder and in pharmaceutical preparation. Methods: Electrochemical behavior of loperamide hydrochloride were investigated using PVC membrane and modified carbon nanotubes paste sensors. The linearity of this developed method was established in the concentration range of 10-5 - 10-2 M and10-6 - 10-2 M shows a Nernstian slope of 57.38 mV and 58.74 mV for PVC and Carbon paste sensor, respectively. Results: Validation parameters such as specificity, linearity, accuracy, precision, stability, limit of detection were found to be within the acceptance limit as studied according to IUPAC recommendation data. Conclusion: Both sensors are successfully applied for potentiometric determination of loperamide hydrochloride in its pure form and pharmaceutical formulations.
Highlights
IntroductionIts molecular weight is 513.5 and its molecular formula is C29H33ClN2O2·HCl. It is a white to slightly yellow powder
Ion selective membrane electrodes of two types: polyvinyl chloride (PVC) membrane and carbon paste electrodes have been constructed for selective determination of loperamide hydrochloride based on the fact that, loperamide behaves as a cation, due to the presence of (-N-) group
Two types of potentiometric electrodes were constructed for determination of loperamide hydrochloride
Summary
Its molecular weight is 513.5 and its molecular formula is C29H33ClN2O2·HCl. It is a white to slightly yellow powder. It is a white to slightly yellow powder It is slightly soluble in water and in dilute acids; freely soluble in chloroform and in methyl alcohol; very slightly soluble in isopropyl alcohol.[1]. Loperamide is a synthetic derivative of pethidine that inhibits gut motility and may reduce gastrointestinal secretions. It is given orally as an antidiarrhoeal drug as an adjunct in the management of acute and chronic diarrhoeas and may be used in the management of colostomies or ileostomies to reduce the volume of discharge.[1]
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