Abstract
Biological proteins embedded in either a biological or an engineered membrane will activelymaintain electrochemical balance across that membrane. In this study two applications willbe examined. First a system of governing equations will be calibrated for a biologicalendosome. The endocytosis predictions presented then serve to validate the model. Inaddition, these predictions introduce new insights into endosome burst, which is ofinterest for advancing DNA vaccine delivery. The calibrated model is subsequentlyadapted to an analogous engineering scenario for targeted payload delivery. In thepresence of a specific external stimulus, burst release of an arbitrary payloadencased in a vesicle akin to an endosome is explored. Control of the process throughmanipulation of vesicle size, stimulus, and transporters is presented. A case is made forapplication of proteins as building blocks in the design of targeted response materials.
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