Abstract
Tetrahedral framework nucleic acid (tFNA), a special DNA nanodevice, is widely applied in diverse biomedical fields. Due to its high programmability, biocompatibility, tissue permeability as well as its capacity for cell proliferation and differentiation, tFNA presents a powerful tool that could overcome potential barriers in the treatment of neurological disorders. This review evaluates recent studies on the use and progress of tFNA-based nanomaterials in neurological disorders.
Highlights
The prevalence of neurological disorders (NDs) has increased in recent years (Feigin et al, 2021)
The results showed that Tetrahedral framework nucleic acid (tFNA) can effectively transfer miR-22 to damaged retinal ganglion cell (RGC) and have a neuroprotective effect on glaucoma
Our analysis shows that the newly synthesized DNA nanomaterials, tFNA, are biocompatible, biodegradable and programmable with size/ structure-controlled membrane permeability
Summary
The prevalence of neurological disorders (NDs) has increased in recent years (Feigin et al, 2021). Recent studies have attempted to apply tFNA-based nanomaterials in the improvement of various neurological disease models and some have shown promising outcomes.
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