Application of PMMA bone cement composited with bone-mineralized collagen in percutaneous kyphoplasty.

Ming Bai,Heping Yin,Yimin Wu,Jian Zhao,Yang Li,Yongdong Yang

doi:10.1093/rb/rbx019

Abstract

We investigated the feasibility of applying polymethylmethacrylate bone cement composited with biomimetic bone-mineralizsed collagen to percutaneous kyphoplasty (PKP). We performed PKP in 95 patients diagnosed with osteoporotic vertebral compression fracture. All patients had fractures of a single vertebral body, and they were divided randomly into control (group A, 47 patients) and experimental (group B, 48 patients) groups. Patients in group A were treated with acrylic cement, and those in group B were treated with acrylic cement composited with the bone graft material. All patients were evaluated by a visual analogue scale (VAS), Oswestry disability index (ODI), Cobb angle and anterior vertebral body height preoperatively, and 3 days and 3 months postoperatively. All patients successfully completed surgery and were followed up thereafter. The VAS score, ODI index, Cobb angle and anterior vertebral body height compression rate in both groups had significant changes (P < 0.05) preoperatively, and at 3 days and 3 months postoperatively. There was no significant difference between the two groups at different times (P > 0.05). The analgesic effects of bone cement composited with bone-mineralized collagen are similar to those of bone cement only. Mineralized collagen has excellent promotion prospects by inducing new bone formation and reducing the incidence of adverse reactions caused by bone cement.

Highlights

Osteoporosis is a fracture-prone systemic disease characterized by osteopenia and bone mass losses
We investigated the feasibility of applying polymethylmethacrylate bone cement composited with biomimetic bone-mineralizsed collagen to percutaneous kyphoplasty (PKP)
Surgery was successful in all patients, and $2–4 ml of bone cement was injected into each vertebra

Summary

Introduction

Osteoporosis is a fracture-prone systemic disease characterized by osteopenia and bone mass losses. It is a progressive disease and a worldwide health problem that affects the quality of life of patients. The incidence of osteoporosis increases with increasing age, and the incidence of osteoporotic vertebral compression fractures is $20% in postmenopausal women. One in three patients suffers from chronic pain in the waist and back This may be because a humpback deformity may cause the chest to become smaller, which affects heart and lung functions to varying degrees. Osteoporosis, combined with low back pain and other symptoms, seriously affects quality of life and has become a major health problem for the elderly, especially for older women. Traditional therapies include bedrest, oral administration of calcium and analgesics, wearing a brace, physiotherapy, rehabilitation therapy and so forth, which has led to a sharp decline in the quality of life of patients and increased mortality

Methods

Results

Conclusion