Abstract
BackgroundThere is a need for other than surgical methods of therapy for small and low rectovaginal fistulas (RVF) in the course of inflammatory bowel diseases (IBD), such as application of fibrin sealants, stem cells, biological therapy, or platelet-rich plasma. The aim of this study was to evaluate the results of the treatment after local application of PRP in aforementioned fistulas, exclusively in the patients with ulcerative colitis (UC).Patients and methodsMedical records of 13 patients with small and low-lying, active RVF in the course of UC, and after restorative proctocolectomy for UC were evaluated. Curettage of fistulous tracts was performed with the following application of PRP in all patients.ResultsComplete closure of RVF was achieved after the first injection in 4 patients, 3 women healed their fistulas following the second application, and two of them closed RVF after 3 injections. To sum up, the complete closure of RVF was achieved in 9 (69%) patients. Fistulas remained closed from 6 to 12 months.ConclusionsThe application of PRP in small, low, and recurrent IBD anal fistulas is effective, simple, and safe with an acceptable rate of healing. This therapy might also precede any further, surgical methods of treatment.
Highlights
Rectovaginal fistula (RVF) is referred to as an epitheliumlined abnormal communication between the rectum and vagina
The overwhelming majority of those fistulas are caused by obstetric injuries, inflammatory bowel diseases (IBD) may result in fistula formation
The aim of this study was to evaluate the results of the treatment after local application of platelet-rich plasma (PRP) in the aforementioned fistulas, exclusively in the patients with ulcerative colitis (UC)
Summary
Rectovaginal fistula (RVF) is referred to as an epitheliumlined abnormal communication between the rectum and vagina. There is a need for other than surgical methods of therapy for small and low rectovaginal fistulas (RVF) in the course of inflammatory bowel diseases (IBD), such as application of fibrin sealants, stem cells, biological therapy, or platelet-rich plasma. The aim of this study was to evaluate the results of the treatment after local application of PRP in aforementioned fistulas, exclusively in the patients with ulcerative colitis (UC). Conclusions The application of PRP in small, low, and recurrent IBD anal fistulas is effective, simple, and safe with an acceptable rate of healing. This therapy might precede any further, surgical methods of treatment
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