Application of plasma NT-proBNP, D-D and serum Lp (a) dynamic monitoring in the diagnosis and evaluation of acute ischemic stroke

Abstract

Objective To investigate the clinical value of plasma N-terminal-pro-B-type natriuretic peptide (NT-proBNP), D-dimer (D-D) and serum lipoprotein(a) [Lp(a)] dynamic monitoring in the dignosis and evaluation of acute ischemic stroke. Methods Seventy-eight patients with acute ischemic stroke were enrolled as study group and 31 healthy subjects examed in the same period were selected as control group. The study group was divided into lacunar cerebral infarction group (n=36) and non-lacunar cerebral infarction group (n=42) according to pathological types, and were divided into mild group (n=25), moderate group (n=28) and severe group (n=25) according to NIHSS score. Fasting venous blood was drawn from all patients, and plasma D-D, NT-proBNP and serum Lp (a) levels were measured by immunoassay and automatic biochemical analyzer. Results The levels of NT-proBNP, D-D and serum Lp(a) in study group were significantly higher than those in control group (P<0.05). In study group, the levels of NT-proBNP, D-D and serum Lp(a) in non-lacunar cerebral infarction group were significantly higher than those in lacunar cerebral infarction group (P<0.05); the differences in the levels of NT-proBNP, DD and serum Lp(a) cross the mild, moderate and severe group were statistically significant (P<0.05), and each index level increased in mild, moderate and severe group, the difference between each two groups was statistically significant (P<0.05). Conclusions The detection of plasma NT-proBNP, D-D and serum Lp(a) can provide a reliable basis for the clinical diagnosis of acute ischemic stroke and contribute to the assessment of disease severity and pathological type. Key words: N-terminal-pro-B-type natriuretic peptide; D-dimer; Lipoprotein (a); Acute ischemic stroke; Diagnostic value